Fisetin
Fisetin
Fisetin

Fisetin

4.8
Rated 4.8 out of 5 stars
4.8 Stars (138 Reviews)

Manages Senescent Cells*
Promotes Cognitive Function*
High Dose of 500mg per capsule!

Manages senescent cells and provides premier antioxidant support.*

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    "Originally the amount of fisetin is why I got it. I'll keep taking it since it's been helpful."

    James B.

    As Seen On
    Fisetin
    fi-set-in
    Fisetin is a polyphenol that's shown to provide incredible support for healthy aging. Among Fisetin's many health benefits, the most notable may be Fisetin's ability to manage dysfunctional cells linked to aging called senescent cells.*
    for healthy aging*
    Manages a Major Cause of Aging
    Senescent cells are a type of dysfunctional cell that accumulate in our body as we age. These dysfunctional cells can get stuck, causing issues linked to accelerated aging. Fisetin has shown in clinical settings to be massively effective at managing senescent cells, helping to support cellular health.*
    Defends Cellular Health
    Oxidative stress caused by free radicals is a key factor linked to aging. Fisetin provides powerful antioxidant activity, helping to protect the body from harmful free radicals.*
    High Dose Per Capsule
    Humanx Fisetin contains 500mg of Fisetin in an easy to swallow capsule, making it easy to meet your daily Fisetin needs.
    Fisetin
    fi-set-in
    for healthy aging*
    Fisetin is a polyphenol that's shown to provide incredible support for healthy aging. Among Fisetin's many health benefits, the most notable may be Fisetin's ability to manage dysfunctional cells linked to aging called senescent cells.*
    Manages a Major Cause of Aging
    Senescent cells are a type of dysfunctional cell that accumulate in our body as we age. These dysfunctional cells can get stuck, causing issues linked to accelerated aging. Fisetin has shown in clinical settings to be massively effective at managing senescent cells, helping to support cellular health.*
    Defends Cellular Health
    Oxidative stress caused by free radicals is a key factor linked to aging. Fisetin provides powerful antioxidant activity, helping to protect the body from harmful free radicals.*
    High Dose Per Capsule
    Humanx Fisetin contains 500mg of Fisetin in an easy to swallow capsule, making it easy to meet your daily Fisetin needs.
    A New Standard in Supplements
    Impeccable Manufacturing Standards
    Every Humanx supplement is manufactured in a CGMP certified facility, this means every supplement:
    • Meets FDA quality standards
    • Contains premium quality ingredients
    • Crafted with exceptional processing methods
    Third Party Testing

    Humanx undergoes rigorous third-party testing because we value complete transparency and you can feel confident you know exactly what you're getting

    Evidence Based Ingredients

    Our ingredients are extensively studied with the world's leading scientists publishing their peer reviewed findings in the National Center of Biotechnical Information

    A New Standard in Supplements

    Impeccable Manufacturing Standards

    Every Humanx supplement is manufactured in a CGMP certified facility, this means every supplement:

    • Meets FDA quality standards
    • Contains premium quality ingredients
    • Crafted with exceptional processing methods

    Third Party Testing

    Humanx undergoes rigorous third-party testing because we value complete trans parency and you can feel confident you know exactly what you're getting

    Evidence Based Ingredients

    Our ingredients are extensively studied with the world's leading scientists publishing their peer reviewed finding in the National Center of Biotechnical Information


    4.8
    Rated 4.8 out of 5 stars
    Based on 138 reviews
    Total 5 star reviews: 122 Total 4 star reviews: 8 Total 3 star reviews: 4 Total 2 star reviews: 2 Total 1 star reviews: 2
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    138 reviews
    • Alexander
      Flag of United States
      Verified Buyer
      5 months ago
      Rated 5 out of 5 stars
      It's real

      I take 1000 mg for two days once a month. It's the best two days of my month. My experiences lead me to believe Fisetin just attacks anything damaged and not just senescent cells. Don't use on workout days. Rest days only. Literally the best money I've ever spent on a supplement

      Was this helpful?
    • Pansy D.
      Verified Buyer
      7 months ago
      Rated 5 out of 5 stars
      Best product

      Absolutely love it

      Was this helpful?
    • Antonia M.
      Verified Buyer
      9 months ago
      Rated 5 out of 5 stars
      This is A Must!

      Fisetin has definitely improved the plaque in my carotid artery. My doctor stated it cut my percentage in half! Thank you Fisetin.

      Was this helpful?
    • Adam B.
      Verified Buyer
      10 months ago
      Rated 5 out of 5 stars
      Cured me EOE

      I love this so far it has changed my life and cured me EoE that I have been fighting for 5 years

      Was this helpful?
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    References

    1. Yousefzadeh MJ, Zhu Y, McGowan SJ, et al. Fisetin is a senotherapeutic that extends health and lifespan. EBioMedicine. 2018. 
    1. Maher P. How fisetin reduces the impact of age and disease on CNS function. Front Biosci (Schol Ed)  2015.
    1. Adhami V.M., Syed D.N., Khan N., Mukhtar H. Dietary flavonoid fisetin: a novel dual inhibitor of PI3K/Akt and mTOR for prostate cancer management. Biochem Pharmacol.2012.  
    1. Zhu Y., Doornebal E.J., Pirtskhalava T., Giorgadze N., Wentworth M., Fuhrmann-Stroissnigg H. New agents that target senescent cells: the flavone, fisetin, and the BCL-XL inhibitors, A1331852 and A1155463. Aging (Albany NY).  2017.
    1. Kirkland J.L., Tchkonia T., Zhu Y., Niedernhofer L.J., Robbins P.D. The clinical potential of senolytic drugs. J Am Geriatr Soc. 2017. 
    1. Khan N, Syed DN, Ahmad N, Mukhtar H. Fisetin: a dietary antioxidant for health promotion. Antioxid Redox Signal. 2013. 
    1. Ishige K. Schubert D. Sagara Y. Flavonoids protect neuronal cells from oxidative stress by three distinct mechanisms. Free Radic Biol Med. 2001. 
    1. Lee SE. Jeong SI. Yang H. Park CS. Jin YH. Park YS. Fisetin induces Nrf2-mediated HO-1 expression through PKC-delta and p38 in human umbilical vein endothelial cells. J Cell Biochem. 2011.

    2. Maher P. Dargusch R. Bodai L. Gerard PE. Purcell JM. Marsh JL. ERK activation by the polyphenols fisetin and resveratrol provides neuroprotection in multiple models of Huntington's disease. Hum Mol Genet. 2011

    3. Syed DN, Adhami VM, Khan MI, Mukhtar H. Inhibition of Akt/mTOR signaling by the dietary flavonoid fisetin. Anticancer Agents Med Chem. 2013.

    4. Sun X, Ma X, Li Q, Yang Y, Xu X, Sun J, Yu M, Cao K, Yang L, Yang G, Zhang G, Wang X. Anti‑cancer effects of fisetin on mammary carcinoma cells via regulation of the PI3K/Akt/mTOR pathway: In vitro and in vivo studies. Int J Mol Med. 2018.

    5. Maher P, Akaishi T, Abe K. Flavonoid fisetin promotes ERK-dependent long-term potentiation and enhances memory. Proc Natl Acad Sci U S A. 2016.

    6. He WB, Abe K, Akaishi T. Oral administration of fisetin promotes the induction of hippocampal long-term potentiation in vivo. J Pharmacol Sci. 2018.
    7. Maher P. Preventing and Treating Neurological Disorders with the Flavonol Fisetin. Brain Plast. 2021.

    8. Ravula AR, Teegala SB, Kalakotla S, Pasangulapati JP, Perumal V, Boyina HK. Fisetin, potential flavonoid with multifarious targets for treating neurological disorders: An updated review. Eur J Pharmacol. 2021.

    9. Gasek, N.S., Kuchel, G.A., Kirkland, J.L. et al.Strategies for targeting senescent cells in human disease. Nat Aging. 2021.

    10. Kubo, Chisato, et al. "Fisetin promotes hair growth by augmenting TERT expression." Frontiers in Cell and Developmental Biology. 2020. 
    1. Zhu M, Meng P, Ling X, Zhou L. Advancements in therapeutic drugs targeting of senescence. Therapeutic Advances in Chronic Disease. 2020.

    2. Chuang JY, Chang PC, et al. Regulatory effects of fisetin on microglial activation. Molecules. 2014.

    3. Iside C, Scafuro M, Nebbioso A, Altucci L. SIRT1 Activation by Natural Phytochemicals: An Overview. Front Pharmacol. 2020.